![]() ![]() Well, unlike many news organisations, we have no sponsors, no corporate or ideological interests. But with a limited number of donor pancreases available for islet transplantation, very few people with type 1 diabetes can currently benefit. This means lots of donor islets are needed to have an impact on blood sugar levels. However, usually about 60% of the donor cells die soon after transplant. They're currently offered to some people with type 1 diabetes who have severe hypos and no awareness of them. In an islet transplant, clusters cells (called islets) from a donor pancreas are transplanted into someone with type 1 diabetes and start to produce insulin. The team will then run experiments to investigate how to scale up the dose of the drugs and how the treatment might work in humans and check if the most promising drug microparticle combinations also work to protect beta cells that have been grown in the lab from stem cells. They will test different combinations of drugs in islet transplants in mice, to see which work best to help islets survive and control blood sugar levels. The team will package microparticles with immune-altering and other drugs to improve the survival of transplanted islets. The team are aiming to improve the benefits and availability of islet transplants by improving the drugs used as part of this treatment. ![]() Researchers from the University of Nottingham's School of Pharmacy and University of Edinburgh have been awarded the funding as part of the Type 1 Diabetes Grand Challenge project to explore better and more innovative ways to improve the effectiveness of transplant islets, clusters of pancreas cells, into people with type 1 diabetes to enable them to make their own insulin. Scientists have been awarded £3m to develop new targeted drugs to help people with Diabetes to make their own insulin that could pave the way for a cure for the disease. ![]()
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